The Landes Research Group at Rice University

The Landes Research Group develops new spectroscopic tools to image chemical dynamics at interfaces at the limit of a single event. Using this super-resolved chemical knowledge, we create new models to understand and predict macroscale processes like protein separation and photocatalysis.

Ensemble vs. Single Molecule

A wide range of biological and materials processes rely on nanoscale interfacial dynamics. Single molecule methods allow us to identify the chemical complexity of these interactions by revealing the underlying populations that form the ensemble measurement. In doing so, we can identify and tune the rare chemical populations that play a crucial role in reactivity.

Towards Predictive Separations

The cost of bringing a new protein based therapeutic to market averages ~$2.6 billion dollars, of which 50% can be dedicated to isolating and purifying the active compound. A primary contributor to the cost is the empirical optimization of chromatographic separation. Our lab seeks to understand separations from the scale of individual analytes, with a goal to create a new predictive model of chromatography to eliminate the need for costly empirical methods.

Breaking the Abbe-Diffraction Limit

The Abbe diffraction limit sets a lower bound of a few hundred nanometers for the size of objects we can observe with traditional optical microscopy. This limit is defined by light’s wavelength. Our lab develops new mathematical methods to break the Abbe diffraction limit and achieve spatial resolutions of just a few nanometers and time resolutions faster than traditional cameras frame times.

Congratulations.   06/20/2023

Zhenyang Jia

Congratulations Zhenyang Jia on passing your Qualifying exam! Best wishes for your future work!

Departmental Achievement Awards   04/28/2023


Congratulations to Selena Zermeño for winning this year's School of Natural Sciences winner of the Staff Service Award!!!, You deserve every success!

Congratulations   04/04/2023

Emily Searles

Congratulations, Emily Searles, on your Ph.D. defense. We will miss you ! Good luck with the coming future!

Congratulations.   03/31/2023

Jagriti ChatterjeeEmil GillettJiamu Lin

Congratulations Jagriti Chatterjee, Emil Gillett and Jiamu Lin on passing your Qualifying Exam. Good luck on the years to come!

Duan, H., Jia,Z., Liaqat, M. ,Mellor, M.D., Tan,H., Nieh, M.P., Lin, Y., Link, S., Landes, C. F., He,J., "Site-Specific Chemistry on Gold Nanorods: Curvature-Guided Surface Dewetting and Supracolloidal Polymerization" ACS Nano 2023 (2023)

Fan, D.,Bajgiran,R.S.,Samghabadi,S.F. ,Dutta, C., Gillett,E., Rossky, P.J., Conrad, J.C., Marciel, B.A., Landes, C. F., "Imaging Heterogeneous 3D Dynamics of Individual Solutes in a Polyelectrolyte Brush" Langmuir 2023, 39, 24, 8532–8539 (2023)

Al-Zubeidi, A.,Wang,Y.,Lin,J.,Flatebo, C., Landes C. F., Ren, H., Link, S., "d-Band Holes React at the Tips of Gold Nanorods" J. Phys. Chem. Lett. 2023, 14, 23, 5297–5304 (2023)

Wallum,A.,Liu,Z.,Lee,J.,Chatterjee, S., Tauzin,L., Barr, C.D., Brown,A., Landes, C. F., Nicely, A.L., Gruebele, M., "An Instrument Assembly and Data Science Lab for Early Undergraduate Education" J. Chem. Educ. 2023 (2023)

Lee, S.A.,Kuhs, C.T., Searles,E.K.,Everitt, H.O., Link,S., Landes, C. F., "d-Band Hole Dynamics in Gold Nanoparticles Measured with Time-Resolved Emission Upconversion Microscopy" Nano Lett. 2023, 23, 8, 3501–3506 (2023)

Gross, N.,Madadi, M., Ostovar,B., Dongare, P. D., McCarthy,L.A., Chiang, W.Y., Chang, W.S.,Halas,N.J., Landes, C. F.,Sader, J.E., Link,S., "Strong Substrate Binding Modulates the Acoustic Quality Factors in Gold Nanodisks" J. Phys. Chem. C 2023, 127, 10, 5054–5066 (2023)

Rice University
Chemistry Department
Smalley-Curl Institute
ECE Department